Structure-Activity Relationships among the Kanamycin Aminoglycosides: Role of Ring I Hydroxyl and Amino Groups

The kanamycins form an important subgroup of the 4,6-disubstituted 2-deoxystreptamine aminoglycoside antibiotics, comprising kanamycin A, kanamycin B, tobramycin, and dibekacin. These compounds interfere with protein synthesis by targeting the ribosomal decoding A site, and they differ in the number...

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Main Authors: Salian, Sumantha, Matt, Tanja, Akbergenov, Rashid, Harish, Shinde, Meyer, Martin, Duscha, Stefan, Shcherbakov, Dmitri, Bernet, Bruno B., Vasella, Andrea, Westhof, Eric, Böttger, Erik C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Chemistry; Biosynthesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497201/
https://ncbi.nlm.nih.gov/pubmed/22948879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01326-12
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