Liposome-Mediated Delivery of Iminosugars Enhances Efficacy against Dengue Virus In Vivo

A key challenge faced by promising antiviral drugs, such as iminosugars, is in vivo delivery to achieve effective levels of drug without toxicity. Four iminosugars, all deoxynojirimycin (DNJ) derivatives—N-butyl DNJ (NB-DNJ), N-nonyl DNJ, N-(9-methoxynonyl) DNJ, and N-(6′-[4″-azido-2″-nitrophenylami...

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Main Authors: Miller, Joanna L., Lachica, Ruben, Sayce, Andrew C., Williams, James P., Bapat, Manisha, Dwek, Raymond, Beatty, P. Robert, Harris, Eva, Zitzmann, Nicole
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497178/
https://ncbi.nlm.nih.gov/pubmed/23070155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01554-12
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