Noninvasive Determination of 2-[(18)F]-Fluoroisonicotinic Acid Hydrazide Pharmacokinetics by Positron Emission Tomography in Mycobacterium tuberculosis-Infected Mice

Tuberculosis (TB) is a global pandemic requiring sustained therapy to facilitate curing and to prevent the emergence of drug resistance. There are few adequate tools to evaluate drug dynamics within infected tissues in vivo. In this report, we evaluated a fluorinated analog of isoniazid (INH), 2-[(1...

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Autori principali: Weinstein, E. A., Liu, L., Ordonez, A. A., Wang, H., Hooker, J. M., Tonge, P. J., Jain, S. K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3497161/
https://ncbi.nlm.nih.gov/pubmed/23006755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01644-12
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