Experimental animal model for mucopolysaccharidosis: suramin-induced glycosaminoglycan and sphingolipid accumulation in the rat.

Intracerebral injection of the trypanocidal drug suramin in rats caused the formation of membranous neuronal and neuroglial inclusions. Here we show that intravenous administration suramin, 500 mg/kg, to 2-month-old rats causes a 5- to 8-fold increase of glycosaminoglycan concentration in the liver...

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Main Authors: Constantopoulos, G, Rees, S, Cragg, B G, Barranger, J A, Brady, R O
Format: Artigo
Jezik:Inglês
Izdano: 1980
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC349686/
https://ncbi.nlm.nih.gov/pubmed/6774343
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