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Randomized, Placebo-Controlled Trial of Mipomersen in Patients with Severe Hypercholesterolemia Receiving Maximally Tolerated Lipid-Lowering Therapy

OBJECTIVES: Mipomersen, an antisense oligonucleotide targeting apolipoprotein B synthesis, significantly reduces LDL-C and other atherogenic lipoproteins in familial hypercholesterolemia when added to ongoing maximally tolerated lipid-lowering therapy. Safety and efficacy of mipomersen in patients w...

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מידע ביבליוגרפי
Main Authors: McGowan, Mary P., Tardif, Jean-Claude, Ceska, Richard, Burgess, Lesley J., Soran, Handrean, Gouni-Berthold, Ioanna, Wagener, Gilbert, Chasan-Taber, Scott
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496741/
https://ncbi.nlm.nih.gov/pubmed/23152839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049006
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