Genetics of cell surface receptors for bioactive polypeptides: Binding of epidermal growth factor is associated with the presence of human chromosome 7 in human-mouse cell hybrids

Mouse A9 cells, L-cell-derived mutants deficient in hypoxanthine phosphoribosyltransferase (HPRT; IMP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) were found to be incapable of binding (125)I-labeled epidermal growth factor (EGF) to the cell surface. The A9 cells were fused with human diploi...

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Bibliographic Details
Main Authors: Shimizu, Nobuyoshi, Behzadian, M. Ali, Shimizu, Yoshiko
Format: Artigo
Language:Inglês
Published: 1980
Subjects:
Biological Sciences: Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC349665/
https://ncbi.nlm.nih.gov/pubmed/6968072
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