Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies

Human uric acid transporter 1 (hURAT1; SLC22A12) is a very important urate anion exchanger. Elevated urate levels are known to play a pivotal role in cardiovascular diseases, chronic renal disease, diabetes, and hypertension. Therefore, the development of potent uric acid transport inhibitors may le...

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Bibliografiset tiedot
Päätekijät: Wempe, Michael F, Lightner, Janet W, Miller, Bettina, Iwen, Timothy J, Rice, Peter J, Wakui, Shin, Anzai, Naohiko, Jutabha, Promsuk, Endou, Hitoshi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Dove Medical Press 2012
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496402/
https://ncbi.nlm.nih.gov/pubmed/23152669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S35805
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