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Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

The dehydratases (DHs) of modular polyketide synthases (PKSs) catalyze dehydrations that occur frequently in the biosynthesis of complex polyketides, yet little is known about them structurally or mechanistically. Here, the structure of a DH domain, isolated from the fourth module of the erythromyci...

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Autor principal: Keatinge-Clay, Adrian
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496180/
https://ncbi.nlm.nih.gov/pubmed/18952099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.09.084
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