Conformational changes during enzyme catalysis: role of water in the transition state.

The entropy of activation for the synthesis of Ile-tRNA is high and positive. The only likely source of a high delta S is the loss of structured water as the enzyme . substrate complex moves toward the transition state. This requires a change in the orientation or nature of water-organizing residues...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Loftfield, R B, Eigner, E A, Pastuszyn, A, Lövgren, T N, Jakubowski, H
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1980
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349618/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6932025/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.6.3374
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