Conformational changes during enzyme catalysis: role of water in the transition state.
The entropy of activation for the synthesis of Ile-tRNA is high and positive. The only likely source of a high delta S is the loss of structured water as the enzyme . substrate complex moves toward the transition state. This requires a change in the orientation or nature of water-organizing residues...
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| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
1980
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349618/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6932025/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.6.3374 |
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