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Conformational changes during enzyme catalysis: role of water in the transition state.

The entropy of activation for the synthesis of Ile-tRNA is high and positive. The only likely source of a high delta S is the loss of structured water as the enzyme . substrate complex moves toward the transition state. This requires a change in the orientation or nature of water-organizing residues...

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Detalhes bibliográficos
Main Authors: Loftfield, R B, Eigner, E A, Pastuszyn, A, Lövgren, T N, Jakubowski, H
Formato: Artigo
Idioma:Inglês
Publicado em: 1980
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC349618/
https://ncbi.nlm.nih.gov/pubmed/6932025
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