Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo

INTRODUCTION: Activation of focal adhesion kinase (FAK) is hypothesized to play an important role in the pathogenesis of human breast cancer. METHODS: To directly evaluate the role of FAK in mammary tumour progression, we have used a conditional FAK mouse model and mouse mammary tumour virus (MMTV)-...

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Autores principales: Lahlou, Hicham, Sanguin-Gendreau, Virginie, Frame, Margaret C, Muller, William J
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496154/
https://ncbi.nlm.nih.gov/pubmed/22373082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3131
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