Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Thalidomide and the immunomodulatory drug, lenalidomide, are therapeutically active in hematological malignancies. The ubiquitously expressed E3 ligase protein cereblon (CRBN) has been identified as the primary teratogenic target of thalidomide. Our studies demonstrate that thalidomide, lenalidomide...

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Bibliografische gegevens
Hoofdauteurs: Lopez-Girona, A, Mendy, D, Ito, T, Miller, K, Gandhi, A K, Kang, J, Karasawa, S, Carmel, G, Jackson, P, Abbasian, M, Mahmoudi, A, Cathers, B, Rychak, E, Gaidarova, S, Chen, R, Schafer, P H, Handa, H, Daniel, T O, Evans, J F, Chopra, R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2012
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496085/
https://ncbi.nlm.nih.gov/pubmed/22552008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.119
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