Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

Thalidomide and the immunomodulatory drug, lenalidomide, are therapeutically active in hematological malignancies. The ubiquitously expressed E3 ligase protein cereblon (CRBN) has been identified as the primary teratogenic target of thalidomide. Our studies demonstrate that thalidomide, lenalidomide...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Lopez-Girona, A, Mendy, D, Ito, T, Miller, K, Gandhi, A K, Kang, J, Karasawa, S, Carmel, G, Jackson, P, Abbasian, M, Mahmoudi, A, Cathers, B, Rychak, E, Gaidarova, S, Chen, R, Schafer, P H, Handa, H, Daniel, T O, Evans, J F, Chopra, R
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2012
נושאים:
Original Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496085/
https://ncbi.nlm.nih.gov/pubmed/22552008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.119
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