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MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant?

In vitro human studies show that the metabolism of most amphetamine-like psychostimulants is regulated by the polymorphic cytochrome P450 isozyme CYP2D6. Two compounds, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA), were selected as archetypes to discuss the translation and clinical s...

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Detalhes bibliográficos
Main Authors: de la Torre, Rafael, Yubero-Lahoz, Samanta, Pardo-Lozano, Ricardo, Farré, Magí
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495276/
https://ncbi.nlm.nih.gov/pubmed/23162568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00235
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