Glucocerebrosidase Mutations alter the endoplasmic reticulum and lysosomes in Lewy body disease

Lewy body disease (LBD) development is enhanced by mutations in the GBA gene coding for glucocerebrosidase (GCase). The mechanism of this association is thought to involve an abnormal lysosomal system and we therefore sought to evaluate if lysosomal changes contribute to the pathogenesis of idiopath...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kurzawa-Akanbi, Marzena, Hanson, Peter S, Blain, Peter G, Lett, Debra J, McKeith, Ian G, Chinnery, Patrick F, Morris, Christopher M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Publishing Ltd 2012
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494984/
https://ncbi.nlm.nih.gov/pubmed/22803570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07879.x
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