Selective loss of glucocerebrosidase activity in sporadic Parkinson’s disease and dementia with Lewy bodies

BACKGROUND: Lysosomal dysfunction is thought to be a prominent feature in the pathogenetic events leading to Parkinson’s disease (PD). This view is supported by the evidence that mutations in GBA gene, coding the lysosomal hydrolase β-glucocerebrosidase (GCase), are a common genetic risk factor for...

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Publicado en:Mol Neurodegener
Autores principales: Chiasserini, Davide, Paciotti, Silvia, Eusebi, Paolo, Persichetti, Emanuele, Tasegian, Anna, Kurzawa-Akanbi, Marzena, Chinnery, Patrick F, Morris, Christopher M, Calabresi, Paolo, Parnetti, Lucilla, Beccari, Tommaso
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428238/
https://ncbi.nlm.nih.gov/pubmed/25881142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0010-2
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