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Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by expanded CAG repeats in the huntingtin (HTT) gene. Although several palliative treatments are available, there is currently no cure and patients generally die 10–15 y after diagnosis. Several promising appr...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494930/ https://ncbi.nlm.nih.gov/pubmed/23054839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206506109 |
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