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Structural analysis of human Cdc20 supports multisite degron recognition by APC/C
The anaphase-promoting complex/cyclosome (APC/C) promotes anaphase onset and mitotic exit through ubiquitinating securin and cyclin B1. The mitotic APC/C activator, the cell division cycle 20 (Cdc20) protein, directly interacts with APC/C degrons––the destruction (D) and KEN boxes. APC/C(Cdc20) is t...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494910/ https://ncbi.nlm.nih.gov/pubmed/23091007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213438109 |
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