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Tolerance and sensitization to chronic escalating-dose heroin following extended withdrawal in Fischer rats: possible role of mu-opioid receptors

RATIONALE/OBJECTIVES: Heroin addiction is characterized by recurrent cycles of drug use, abstinence and relapse. It is likely that neurobiological changes during chronic heroin exposure persist across withdrawal and impact behavioral responses to re-exposure. We hypothesized that, after extended wit...

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Detalhes bibliográficos
Main Authors: Seip-Cammack, Katharine M., Reed, Brian, Zhang, Yong, Ho, Ann, Kreek, Mary Jeanne
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494815/
https://ncbi.nlm.nih.gov/pubmed/22829433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-012-2801-2
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