Modeling the Role of Negative Cooperativity in Metabolic Regulation and Homeostasis

A significant proportion of enzymes display cooperativity in binding ligand molecules, and such effects have an important impact on metabolic regulation. This is easiest to understand in the case of positive cooperativity. Sharp responses to changes in metabolite concentrations can allow organisms t...

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Autores principales: Bush, Eliot C., Clark, Anne E., DeBoever, Chris M., Haynes, Lillian E., Hussain, Sidra, Ma, Singer, McDermott, Matthew M., Novak, Adam M., Wentworth, John S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494708/
https://ncbi.nlm.nih.gov/pubmed/23152821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048920
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