Modeling the Role of Negative Cooperativity in Metabolic Regulation and Homeostasis

A significant proportion of enzymes display cooperativity in binding ligand molecules, and such effects have an important impact on metabolic regulation. This is easiest to understand in the case of positive cooperativity. Sharp responses to changes in metabolite concentrations can allow organisms t...

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Detalhes bibliográficos
Main Authors: Bush, Eliot C., Clark, Anne E., DeBoever, Chris M., Haynes, Lillian E., Hussain, Sidra, Ma, Singer, McDermott, Matthew M., Novak, Adam M., Wentworth, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494708/
https://ncbi.nlm.nih.gov/pubmed/23152821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048920
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