ScFv Anti-Heparan Sulfate Antibodies Unexpectedly Activate Endothelial and Cancer Cells through p38 MAPK: Implications for Antibody-Based Targeting of Heparan Sulfate Proteoglycans in Cancer

Tumor development requires angiogenesis and anti-angiogenic therapies have been introduced in the treatment of cancer. In this context, heparan sulfate proteoglycans (HSPGs) emerge as interesting targets, owing to their function as co-receptors of major, pro-angiogenic factors. Accordingly, previous...

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Bibliografiska uppgifter
Huvudupphovsmän: Christianson, Helena C., van Kuppevelt, Toin H., Belting, Mattias
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494658/
https://ncbi.nlm.nih.gov/pubmed/23152853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049092
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