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Combinatorial Immunotherapy: PD-1 may not be LAG-ing behind any more

Cancer immunotherapy attempts to harness the immune system by breaking tolerance and generating a robust anticancer response. We have recently demonstrated a synergistic enhancement in tumor clearance following therapeutic, dual PD-1 and LAG-3 blockade. Here, we discuss the implications of these fin...

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Autori principali: Turnis, Meghan E., Korman, Alan J., Drake, Charles G., Vignali, Dario A.A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494635/
https://ncbi.nlm.nih.gov/pubmed/23170269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.20593
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