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Inhibitory receptors as targets for cancer immunotherapy

Inhibitory receptors expressed on T cells control immune responses while limiting autoimmunity. However, tumors can hijack these ‘checkpoints’ for protection from immune attack. Tumor-specific T cells that exhibit an exhausted, unresponsive phenotype express high levels of inhibitory receptors inclu...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Turnis, Meghan E., Andrews, Lawrence P., Vignali, Dario A. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4549156/
https://ncbi.nlm.nih.gov/pubmed/26018646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201344413
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