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B7-H1 limits the entry of effector CD8(+) T cells to the memory pool by upregulating Bim
Protective T‑cell immunity against cancer and infections is dependent on the generation of a durable effector and memory T‑cell pool. Studies from cancer and chronic infections reveal that B7-H1 (PD-L1) engagement with its receptor PD-1 promotes apoptosis of effector T cells. It is not clear how B7-...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494620/ https://ncbi.nlm.nih.gov/pubmed/23170254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.20850 |
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