B7-H1 limits the entry of effector CD8(+) T cells to the memory pool by upregulating Bim

Protective T‑cell immunity against cancer and infections is dependent on the generation of a durable effector and memory T‑cell pool. Studies from cancer and chronic infections reveal that B7-H1 (PD-L1) engagement with its receptor PD-1 promotes apoptosis of effector T cells. It is not clear how B7-...

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Hlavní autoři: Gibbons, Rachel M., Liu, Xin, Pulko, Vesna, Harrington, Susan M., Krco, Christopher J., Kwon, Eugene D., Dong, Haidong
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494620/
https://ncbi.nlm.nih.gov/pubmed/23170254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.20850
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