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Splicing Up Mdm2 for Cancer Proteome Diversity

Cancer cells often have high expression of Mdm2. However, in many cancers mdm2 is alternatively spliced, with more than 40 mRNA variants identified. Many of the alternative spliced mdm2 mRNAs have the potential to encode truncated Mdm2 isoforms. These putative Mdm2 isoforms can theoretically increas...

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Bibliografiska uppgifter
Huvudupphovsmän: Okoro, Danielle R., Rosso, Melissa, Bargonetti, Jill
Materialtyp: Artigo
Språk:Inglês
Publicerad: SAGE Publications 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494376/
https://ncbi.nlm.nih.gov/pubmed/23150764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601912455323
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