C2 domain membrane penetration by group IVA cytosolic phospholipase A(2) induces membrane curvature changes

Group IVA cytosolic phospholipase A(2) (cPLA(2)α) is an 85 kDa enzyme that regulates the release of arachidonic acid (AA) from the sn-2 position of membrane phospholipids. It is well established that cPLA(2)α binds zwitterionic lipids such as phosphatidylcholine in a Ca(2+)-dependent manner through...

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Bibliographische Detailangaben
Hauptverfasser: Ward, Katherine E., Ropa, James P., Adu-Gyamfi, Emmanuel, Stahelin, Robert V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494261/
https://ncbi.nlm.nih.gov/pubmed/22991194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M030718
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