Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice

Genetic studies link inherited errors in RNA metabolism to familial neurodegenerative disease. Here, we report such errors and the underlying mechanism in sporadic Alzheimer's disease (AD). AD entorhinal cortices presented globally impaired exon exclusions and selective loss of the hnRNP A/B sp...

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Main Authors: Berson, Amit, Barbash, Shahar, Shaltiel, Galit, Goll, Yael, Hanin, Geula, Greenberg, David S, Ketzef, Maya, Becker, Albert J, Friedman, Alon, Soreq, Hermona
Format: Artigo
Jezik:Inglês
Izdano: WILEY-VCH Verlag 2012
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494073/
https://ncbi.nlm.nih.gov/pubmed/22628224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100995
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