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Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice

Genetic studies link inherited errors in RNA metabolism to familial neurodegenerative disease. Here, we report such errors and the underlying mechanism in sporadic Alzheimer's disease (AD). AD entorhinal cortices presented globally impaired exon exclusions and selective loss of the hnRNP A/B sp...

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書誌詳細
主要な著者: Berson, Amit, Barbash, Shahar, Shaltiel, Galit, Goll, Yael, Hanin, Geula, Greenberg, David S, Ketzef, Maya, Becker, Albert J, Friedman, Alon, Soreq, Hermona
フォーマット: Artigo
言語:Inglês
出版事項: WILEY-VCH Verlag 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494073/
https://ncbi.nlm.nih.gov/pubmed/22628224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100995
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