Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice

Genetic studies link inherited errors in RNA metabolism to familial neurodegenerative disease. Here, we report such errors and the underlying mechanism in sporadic Alzheimer's disease (AD). AD entorhinal cortices presented globally impaired exon exclusions and selective loss of the hnRNP A/B sp...

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Detalhes bibliográficos
Main Authors: Berson, Amit, Barbash, Shahar, Shaltiel, Galit, Goll, Yael, Hanin, Geula, Greenberg, David S, Ketzef, Maya, Becker, Albert J, Friedman, Alon, Soreq, Hermona
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494073/
https://ncbi.nlm.nih.gov/pubmed/22628224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100995
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