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Cyclin-dependent Kinase-1 (Cdk1)/Cyclin B1 Dictates Cell Fate after Mitotic Arrest via Phosphoregulation of Antiapoptotic Bcl-2 Proteins

The prevailing model suggests that cell fate after mitotic arrest depends on two independent and competing networks that control cyclin B1 degradation and the generation of death signals. However, recent evidence for Cdk1/cyclin B1-mediated phosphorylation and inactivation of antiapoptotic Bcl-2 pro...

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Bibliografiske detaljer
Main Authors: Sakurikar, Nandini, Eichhorn, Joshua M., Chambers, Timothy C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493959/
https://ncbi.nlm.nih.gov/pubmed/22965228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.391854
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