A Common Mechanism of Inhibition of the Mycobacterium tuberculosis Mycolic Acid Biosynthetic Pathway by Isoxyl and Thiacetazone

Isoxyl (ISO) and thiacetazone (TAC), two prodrugs once used in the clinical treatment of tuberculosis, have long been thought to abolish Mycobacterium tuberculosis (M. tuberculosis) growth through the inhibition of mycolic acid biosynthesis, but their respective targets in this pathway have remained...

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Detalhes bibliográficos
Main Authors: Grzegorzewicz, Anna E., Korduláková, Jana, Jones, Victoria, Born, Sarah E. M., Belardinelli, Juan M., Vaquié, Adrien, Gundi, Vijay A. K. B., Madacki, Jan, Slama, Nawel, Laval, Françoise, Vaubourgeix, Julien, Crew, Rebecca M., Gicquel, Brigitte, Daffé, Mamadou, Morbidoni, Hector R., Brennan, Patrick J., Quémard, Annaik, McNeil, Michael R., Jackson, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493888/
https://ncbi.nlm.nih.gov/pubmed/23002234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400994
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