Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells

BACKGROUND: Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer stem cells (CSCs) are a key mediator of chemoresistance. We have reported that disulfiram (DS), an aldehyde dehydrogenase (ALDH) inhibitor, targets breast CSC-like cells. In this study, the effect of DS and com...

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Main Authors: Liu, P, Brown, S, Goktug, T, Channathodiyil, P, Kannappan, V, Hugnot, J-P, Guichet, P-O, Bian, X, Armesilla, A L, Darling, J L, Wang, W
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493777/
https://ncbi.nlm.nih.gov/pubmed/23033007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.442
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