Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties

BACKGROUND: Previous studies indicate that disulfiram (DS), an anti-alcoholism drug, is cytotoxic to cancer cell lines and reverses anticancer drug resistance. Cancer stem cells (CSCs) are the major cause of chemoresistance leading to the failure of cancer chemotherapy. This study intended to examin...

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Autors principals: Yip, N C, Fombon, I S, Liu, P, Brown, S, Kannappan, V, Armesilla, A L, Xu, B, Cassidy, J, Darling, J L, Wang, W
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
Matèries:
Translational Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101904/
https://ncbi.nlm.nih.gov/pubmed/21487404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.126
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