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Prion protein facilitates uptake of zinc into neuronal cells

Zinc is released into the synaptic cleft upon exocytotic stimuli, although the mechanism for its reuptake into neurons is unresolved. Here we show that the cellular prion protein enhances the uptake of zinc into neuronal cells. This prion-protein-mediated zinc influx requires the octapeptide repeats...

詳細記述

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書誌詳細
主要な著者: Watt, Nicole T., Taylor, David R., Kerrigan, Talitha L., Griffiths, Heledd H., Rushworth, Jo V., Whitehouse, Isobel J., Hooper, Nigel M.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Pub. Group 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493655/
https://ncbi.nlm.nih.gov/pubmed/23072804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2135
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