Changes in JC Virus-Specific T Cell Responses during Natalizumab Treatment and in Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) induced by JC virus (JCV) is a risk for natalizumab-treated multiple sclerosis (MS) patients. Here we characterize the JCV-specific T cell responses in healthy donors and natalizumab-treated MS patients to reveal functional differences that may accoun...

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Detalhes bibliográficos
Main Authors: Perkins, Molly R., Ryschkewitsch, Caroline, Liebner, Julia C., Monaco, Maria Chiara G., Himelfarb, Danielle, Ireland, Sara, Roque, Annelys, Edward, Heather L., Jensen, Peter N., Remington, Gina, Abraham, Thomas, Abraham, Jaspreet, Greenberg, Benjamin, Kaufman, Charles, LaGanke, Chris, Monson, Nancy L., Xu, Xiaoning, Frohman, Elliot, Major, Eugene O., Douek, Daniel C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493478/
https://ncbi.nlm.nih.gov/pubmed/23144619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003014
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