Changes in JC Virus-Specific T Cell Responses during Natalizumab Treatment and in Natalizumab-Associated Progressive Multifocal Leukoencephalopathy

Progressive multifocal leukoencephalopathy (PML) induced by JC virus (JCV) is a risk for natalizumab-treated multiple sclerosis (MS) patients. Here we characterize the JCV-specific T cell responses in healthy donors and natalizumab-treated MS patients to reveal functional differences that may accoun...

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Autori principali: Perkins, Molly R., Ryschkewitsch, Caroline, Liebner, Julia C., Monaco, Maria Chiara G., Himelfarb, Danielle, Ireland, Sara, Roque, Annelys, Edward, Heather L., Jensen, Peter N., Remington, Gina, Abraham, Thomas, Abraham, Jaspreet, Greenberg, Benjamin, Kaufman, Charles, LaGanke, Chris, Monson, Nancy L., Xu, Xiaoning, Frohman, Elliot, Major, Eugene O., Douek, Daniel C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493478/
https://ncbi.nlm.nih.gov/pubmed/23144619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003014
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