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Structural and Functional Insights into the HIV-1 Maturation Inhibitor Binding Pocket
Processing of the Gag precursor protein by the viral protease during particle release triggers virion maturation, an essential step in the virus replication cycle. The first-in-class HIV-1 maturation inhibitor dimethylsuccinyl betulinic acid [PA-457 or bevirimat (BVM)] blocks HIV-1 maturation by inh...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3493477/ https://ncbi.nlm.nih.gov/pubmed/23144615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002997 |
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