Skin tumor promotion by phorbol esters is a two-stage process.

In the semisynthetic compound phorbol 12-retinoate 13-acetate (PRA), the antipromoting principle of vitamin A acid is combined with the structure of a phorbol ester tumor promoter. In skin of NMRI mice, a single topical application of PRA induces skin inflammation, epidermal proliferation, and susta...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Fürstenberger, G, Berry, D L, Sorg, B, Marks, F
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1981
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349342/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6801661/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.12.7722
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