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Specific binding of phorbol ester tumor promoters

[20-(3)H]Phorbol 12,13-dibutyrate bound to particulate preparations from chicken embryo fibroblasts in a specific, saturable, reversible fashion. Equilibrium binding occurred with a K(d) of 25 nM; this value is very close to the 50% effective dose (ED(50)), 50 nM, previously determined for the biolo...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Driedger, Paul E., Blumberg, Peter M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 1980
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348314/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6965793/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.1.567
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