Skin tumor promotion by phorbol esters is a two-stage process.
In the semisynthetic compound phorbol 12-retinoate 13-acetate (PRA), the antipromoting principle of vitamin A acid is combined with the structure of a phorbol ester tumor promoter. In skin of NMRI mice, a single topical application of PRA induces skin inflammation, epidermal proliferation, and susta...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1981
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349342/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6801661/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.12.7722 |
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