Modulation of gastrointestinal function by MuDelta, a mixed µ opioid receptor agonist/ µ opioid receptor antagonist

BACKGROUND & PURPOSE: Loperamide is a selective µ opioid receptor agonist acting locally in the gastrointestinal (GI) tract as an effective anti-diarrhoeal but can cause constipation. We tested whether modulating µ opioid receptor agonism with δ opioid receptor antagonism, by combining reference...

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Detalhes bibliográficos
Main Authors: Wade, PR, Palmer, JM, McKenney, S, Kenigs, V, Chevalier, K, Moore, BA, Mabus, JR, Saunders, PR, Wallace, NH, Schneider, CR, Kimball, ES, Breslin, HJ, He, W, Hornby, PJ
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492991/
https://ncbi.nlm.nih.gov/pubmed/22671931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02068.x
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