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Ligand-directed signalling within the opioid receptor family
The classic model of GPCR activation proposed that all agonists induce the same active receptor conformation. However, research over the last decade has shown that GPCRs exist in multiple conformations, and that agonists can stabilize different active states. The distinct receptor conformations indu...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3492979/ https://ncbi.nlm.nih.gov/pubmed/22708627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02075.x |
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