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Ligand-directed signalling within the opioid receptor family

The classic model of GPCR activation proposed that all agonists induce the same active receptor conformation. However, research over the last decade has shown that GPCRs exist in multiple conformations, and that agonists can stabilize different active states. The distinct receptor conformations indu...

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Bibliografski detalji
Glavni autori: Pradhan, Amynah A, Smith, Monique L, Kieffer, Brigitte L, Evans, Christopher J
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492979/
https://ncbi.nlm.nih.gov/pubmed/22708627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02075.x
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