Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats

To investigate the role of the pro-inflammatory cytokine interleukin-1β (IL-1β) in postoperative cognitive dysfunction (POCD) in aged rats, we used laparotomy to mimic human abdominal surgery in adult (3 months) and aged (24 months) F344/BN rats. We demonstrated that memory consolidation of the hipp...

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Main Authors: Barrientos, Ruth M., Hein, Amy M., Frank, Matthew G., Watkins, Linda R., Maier, Steven F.
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2012
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492959/
https://ncbi.nlm.nih.gov/pubmed/23077050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2173-12.2012
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