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Targeting 4-1BB (CD137) to enhance CD8 T cell responses with poxviruses and viral antigens

Attenuated vaccinia virus (VACV) vectors are considered prime vaccine candidates for use in immunotherapy of infectious disease. In spite of this, recent data show that the level of attenuation may hamper the efficient generation of protective CD8 T cells. This suggests that additional adjuvant-like...

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Bibliografische gegevens
Hoofdauteurs: Zhao, Yuan, Tahiliani, Vikas, Salek-Ardakani, Shahram, Croft, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492829/
https://ncbi.nlm.nih.gov/pubmed/23162550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2012.00332
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