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Coupling of epithelial Na(+) and Cl(−) channels by direct and indirect activation by serine proteases
The mammalian collecting duct (CD) is continuously exposed to urinary proteases. The CD expresses an epithelial Na(+) channel (ENaC) that is activated after cleavage by serine proteases. ENaC also exists at the plasma membrane in the uncleaved form, rendering activation by extracellular proteases an...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3492828/ https://ncbi.nlm.nih.gov/pubmed/22914644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00395.2011 |
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