Swainsonine: an inhibitor of glycoprotein processing.
Swainsonine, an indolizidine alkaloid, inhibits the processing of asparagine-linked glycoproteins in both cell-free extracts and animal cells in culture. Thus, in a liver particulate enzyme preparation, swainsonine at 0.1-1.0 microM inhibited the mannosidase that releases [3H]mannose from a high man...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1981
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349273/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6801650/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.12.7393 |
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