Use of the Comet-FISH Assay to Compare DNA Damage and Repair in p53 and hTERT Genes following Ionizing Radiation

The alkaline single cell gel electrophoresis (comet) assay can be combined with fluorescent in situ hybridisation (FISH) methodology in order to investigate the localisation of specific gene domains within an individual cell. The number and position of the fluorescent signal(s) provides information...

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Main Authors: McKenna, Declan J., Doherty, Bernadette A., Downes, C. Stephen, McKeown, Stephanie R., McKelvey-Martin, Valerie J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492288/
https://ncbi.nlm.nih.gov/pubmed/23145163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049364
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