Use of the Comet-FISH Assay to Compare DNA Damage and Repair in p53 and hTERT Genes following Ionizing Radiation

The alkaline single cell gel electrophoresis (comet) assay can be combined with fluorescent in situ hybridisation (FISH) methodology in order to investigate the localisation of specific gene domains within an individual cell. The number and position of the fluorescent signal(s) provides information...

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Main Authors: McKenna, Declan J., Doherty, Bernadette A., Downes, C. Stephen, McKeown, Stephanie R., McKelvey-Martin, Valerie J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3492288/
https://ncbi.nlm.nih.gov/pubmed/23145163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049364
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